Cosmic Peptides research library

N-terminal acetylation

Capping a peptide's free N-terminal amine with an acetyl group, which removes its positive charge.

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N-terminal acetylation adds an acetyl group (CH3CO–) to the N-terminal amine, adding 42.01 Da and removing a positive charge. Like C-terminal amidation, it is part of a peptide's defined structure and can increase resistance to aminopeptidases in vitro.

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For in vitro laboratory research only. Not for human or veterinary use. This library describes chemistry, analytical methods and published laboratory research; it gives no guidance on use in people or animals.